Evidence supporting the use of: Vitamin D
For the body system: Joints

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin D is scientifically validated to play a role in joint and musculoskeletal health, though its primary functions are in calcium homeostasis and bone metabolism rather than direct joint support. Vitamin D deficiency has been associated with increased risk of osteomalacia in adults and rickets in children, both of which feature musculoskeletal pain and weakness. Observational studies have found that people with low vitamin D levels are more likely to report joint pain and are at higher risk for development of conditions such as osteoarthritis and rheumatoid arthritis. Some clinical trials have investigated vitamin D supplementation in people with these conditions, with mixed results: some report modest reductions in pain and improvement in function, while others find no significant benefit. The mechanisms proposed include vitamin D's role in immune modulation and reduction of inflammation, which could theoretically help in inflammatory joint diseases. However, while vitamin D supplementation is generally recommended for bone health, especially in populations at risk for deficiency, its direct and consistent benefit for joint health is less robustly established. Most guidelines recommend vitamin D primarily for bone, rather than joint, health, but maintaining adequate vitamin D status may be beneficial as part of overall musculoskeletal support. Overall, the evidence supports a moderate relationship between vitamin D and joint health, particularly in the context of deficiency.

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