Synopsis

Source of validity: Scientific
Rating (out of 5): 3

S-adenosylmethionine (SAM-e) has been investigated for its potential benefits in supporting joint health, particularly in the management of osteoarthritis. Several clinical studies and systematic reviews have examined its efficacy. SAM-e appears to have anti-inflammatory and analgesic properties, which may alleviate joint pain and improve function. A number of randomized controlled trials (RCTs) have compared SAM-e to nonsteroidal anti-inflammatory drugs (NSAIDs) and placebo. Some studies suggest that SAM-e provides similar pain relief to NSAIDs, with fewer gastrointestinal side effects. For example, a 2002 meta-analysis published in BMC Musculoskeletal Disorders concluded that SAM-e was more effective than placebo and as effective as NSAIDs for reducing pain and improving functional limitation in osteoarthritis patients. The proposed mechanism involves SAM-e’s role in cartilage proteoglycan synthesis and anti-inflammatory methylation reactions.

However, while evidence favors its use over placebo and indicates comparability to NSAIDs, the quality of studies is variable, with some having small sample sizes and methodological limitations. As such, while SAM-e is scientifically validated to some extent for joint support, the evidence is moderate rather than strong. Clinical guidelines do not routinely recommend its use, but it is considered an option for patients who cannot tolerate NSAIDs. Thus, SAM-e’s use for joint support is supported by moderate scientific evidence but requires further large-scale, high-quality trials for definitive conclusions.

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Other ingredients that support Joints

alfalfa
algal oil
amino acids
berry flavor
beta caryophyllene
black cumin
black currant
sesame
borage oil
boron
Indian frankincense
bovine
bovine gelatin
broccoli
bromelain
burdock
cabbage leaf
calamari oil
cartilage
cat's claw
cherry
Chinese salvia root
chondroitin
cissus quadrangularis
collagen
turmeric
curcumin
cuspidatum root
devil's claw
dog rose
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
evening primrose oil
fish oil
fish protein
flavonols
flaxseed
gamma linolenic acid (GLA)
gelatin
ginger
glucosamine
gokhru
gooseberry
gotu kola
green lipped mussel
guggul
horsetail
hyaluronic acid
Indian tinospora
knotweed
krill oil
l-proline
mackerel
manganese
marine lipid
methylsulfonylmethane (MSM)
microcrystalline hydroxyapatite concentrate (MCHC)
milk
moringa
mustard seed
n-acetyl-glucosamine
nettle
olive
omega-3 fatty acids
omega-6 fatty acids
phellodendron amurense
phytocannabinoids
pine bark
pineapple
plantain
protein
quercetin
rehmannia glutinosa
rhizome
rose hips
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sardines
scrophularia root
serratiopeptidase
silicon
black ginger
specialized pro-resolving mediators (SPMs)
triphala
vitamin C
vitamin D
seaweed
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white willow
wild yam
sarsaparilla
red clover
boneset
chickweed
gastrodia
capsicum
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punarnava
commiphora
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polyphenols
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camphor oil
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gentiana macrophylla
noni
herbal blend (proprietary)
algae
cayenne pepper
ashitaba
gravel root
bladderwrack
arnica
clematis
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
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Animal Tissue
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Avian Cartilage
Achyranthes
Anamu
Avocado
Asteracea
Acetylsalicylic acid
Abuta
Amor seco
Animal protein
Bone
Black Seed
Baikal Skullcap
Bryonia
Biopeptide
Babchi
Bidens pilosa
Balsam
Bishop's Weed
Boswellic Acid
Bayleaf
Butea monosperma
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Barleria
Bugbane
Baicalein
Bovine Protein
berry
Bogbean
Black Gram
Boswellia
Black Poplar
Black willow
Ba Ji Tian
Bone Protein
Bee products
Bombax
Borage
bovine cartilage / glycosaminoglycan
Baicalin
Bassia scoparia
Bee venom
Bergenia
Boerhavia diffusa
Curculigo orchicides
Comfrey
Centella triterpenes
Chinese Silkvine
Caryophyllene
Cinnamomum
Chinese Mountain Ant
Crustaceans
Cod Liver Oil
Coriander
Clerodendrum phlomidis
Cinquefoil
Cyathula
Curcuminoid
Capsaicin
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Curcumen
Cymbopogon Martini
Centella asiatica
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Cissus sicyoides
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Campsiandra angustifolia
Cowslip
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Carthamus
Copaiba Oil
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Deer Root
Deer Velvet
Drynaria
Devil's Club
Dwarf Nettle
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Dipsacus
Elephant Vine
Egg
Elk antler
Emu Oil
Eicosapentaenoic Acid
Evening Primrose Oil
European-Five Finger Grass
Escin
Eucommia ulmoides
Ecklonia
Figwort
Flavonoids
Fang-Feng
Fructoborate
Fish
Fatty acids
Flemingia philippinensis
Frankincense
Fir
Gnaphalium
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Glycine
Garden Cress
Glycosaminoglycans
Guggulsterones
Golden Willow
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Heartsease
Little ironweed
Shellfish
silica

Other body systems supported by SAM-e

Brain
Dopamine
Hepatic System
Joints
Liver
Serotonin

Products containing SAM-e

We currently have no products on Caring Sunshine that contain this ingredient.