Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Pycnogenol, a standardized extract from the bark of the French maritime pine (Pinus pinaster), has been studied for its potential benefits in supporting joint health. The scientific rationale primarily centers on its antioxidant and anti-inflammatory properties. Several clinical trials and reviews have investigated Pycnogenol’s effects on osteoarthritis and related joint conditions. For example, a randomized, double-blind, placebo-controlled study published in Phytotherapy Research (2007) found that Pycnogenol supplementation (100 mg/day for 3 months) resulted in significant improvement in joint pain, stiffness, and physical function in patients with osteoarthritis of the knee compared to placebo. Another study in Phytotherapy Research (2008) reported reduced need for analgesic medication and improved symptoms in osteoarthritis patients taking Pycnogenol.

The proposed mechanisms involve inhibition of inflammatory mediators such as COX-2 and reduction of matrix metalloproteinases that degrade cartilage. Some in vitro and animal studies also support these anti-inflammatory and chondroprotective effects. However, the overall number of high-quality human trials is modest, with some heterogeneity in findings. While there is no major traditional use of Pycnogenol specifically for joint health, the available scientific evidence suggests a moderate level of support for its use in this context, justifying a rating of 3 out of 5. Further large-scale and long-term studies are still needed to firmly establish efficacy and safety.

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