Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Glucosamine is commonly used as a dietary supplement to support joint health, particularly for conditions like osteoarthritis. The rationale stems from its role as a natural compound found in cartilage, where it helps build and maintain joint tissue.

Several randomized controlled trials and meta-analyses have investigated the efficacy of glucosamine for osteoarthritis, especially of the knee. Some studies have reported modest benefits in reducing pain and improving joint function, while others have found no significant effect compared to placebo. The largest and most rigorous trials, such as the GAIT trial funded by the National Institutes of Health, found that glucosamine (alone or with chondroitin) was not significantly better than placebo for pain relief in most participants, though a subset with moderate-to-severe pain did appear to benefit.

Systematic reviews and guidelines, including those from the American College of Rheumatology and the Osteoarthritis Research Society International, generally conclude that the evidence for glucosamine is mixed and does not robustly support its routine use for joint health. However, it is considered safe for most people, and some individuals report subjective improvement.

In summary, glucosamine's use for joint support is based on scientific rationale and has been investigated in clinical research, but the strength of evidence for its efficacy is modest at best, justifying a rating of 2 out of 5.

More about glucosamine
More about Joints

Other ingredients that support Joints

Other body systems supported by glucosamine

Products containing glucosamine

Nature's Sunshine Everflex with Hyaluronic Acid
Nature's Sunshine Glucosamine
Nature's Sunshine Solstic Revive
Nature's Sunshine Structural System (30 Day Program)