Evidence supporting the use of: Evening Primrose
For the body system: Joints
Synopsis
Source of validity: Traditional
Rating (out of 5): 2
Evening Primrose (Oenothera biennis) has been traditionally used to support joint health, particularly in the context of conditions like rheumatoid arthritis. The oil extracted from its seeds contains gamma-linolenic acid (GLA), an omega-6 fatty acid thought to have anti-inflammatory properties. Traditional herbal medicine systems, especially in Europe and North America, have used evening primrose oil (EPO) to alleviate symptoms such as joint pain and stiffness.
Some small clinical studies and reviews have explored EPO’s effects on joint health, especially in rheumatoid arthritis. However, results are mixed—while a few studies reported mild improvements in pain and morning stiffness, the overall evidence is inconsistent and often limited by study quality, size, and methodology. For osteoarthritis, there is even less supportive data. Major reviews, including those by the Cochrane Collaboration, generally conclude that there is insufficient robust evidence to recommend evening primrose oil as an effective treatment for joint conditions.
In summary, the use of evening primrose oil for joint support is primarily based on traditional uses and limited preliminary research rather than strong scientific validation. People considering EPO for joint health should consult healthcare professionals, as it should not replace proven medical therapies.
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alfalfaalgal oil
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berry flavor
beta caryophyllene
black cumin
black currant
sesame
borage oil
boron
Indian frankincense
bovine
bovine gelatin
broccoli
bromelain
burdock
cabbage leaf
calamari oil
cartilage
cat's claw
cherry
Chinese salvia root
chondroitin
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collagen
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curcumin
cuspidatum root
devil's claw
dog rose
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
evening primrose oil
fish oil
fish protein
flavonols
flaxseed
gamma linolenic acid (GLA)
gelatin
ginger
glucosamine
gokhru
gooseberry
gotu kola
green lipped mussel
guggul
horsetail
hyaluronic acid
Indian tinospora
knotweed
krill oil
l-proline
mackerel
manganese
marine lipid
methylsulfonylmethane (MSM)
microcrystalline hydroxyapatite concentrate (MCHC)
milk
moringa
mustard seed
n-acetyl-glucosamine
nettle
olive
omega-3 fatty acids
omega-6 fatty acids
phellodendron amurense
phytocannabinoids
pine bark
pineapple
plantain
protein
quercetin
rehmannia glutinosa
rhizome
rose hips
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sardines
scrophularia root
serratiopeptidase
silicon
black ginger
specialized pro-resolving mediators (SPMs)
triphala
vitamin C
vitamin D
seaweed
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white willow
wild yam
sarsaparilla
red clover
boneset
chickweed
gastrodia
capsicum
clerodendrum indicum
hedychium spicatum
punarnava
commiphora
paederia foetida
smilax
tinospora cordifolia
rubia cordifolia
chaff flower
peony
lingusticum wallichii
prickly ash
myrrh
juniper berries
solomon's seal
siler root
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dioscorea
teasel
eucommia
ganoderma
morinda
zanthoxylum
birch
queen of the meadow
polyphenols
anemarrhena asphodeloides
yucca
barrenwort
wintergreen
camphor oil
coix
gentiana macrophylla
noni
herbal blend (proprietary)
algae
cayenne pepper
ashitaba
gravel root
bladderwrack
arnica
clematis
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Aralia
Animal Tissue
Antler
Avian Cartilage
Achyranthes
Anamu
Avocado
Asteracea
Acetylsalicylic acid
Abuta
Amor seco
Animal protein
Bone
Black Seed
Baikal Skullcap
Bryonia
Biopeptide
Babchi
Bidens pilosa
Balsam
Bishop's Weed
Boswellic Acid
Bayleaf
Butea monosperma
Black galingale
Barleria
Bugbane
Baicalein
Bovine Protein
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Bogbean
Black Gram
Boswellia
Black Poplar
Black willow
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Bone Protein
Bee products
Bombax
Borage
bovine cartilage / glycosaminoglycan
Baicalin
Bassia scoparia
Bee venom
Bergenia
Boerhavia diffusa
Curculigo orchicides
Comfrey
Centella triterpenes
Chinese Silkvine
Caryophyllene
Cinnamomum
Chinese Mountain Ant
Crustaceans
Cod Liver Oil
Coriander
Clerodendrum phlomidis
Cinquefoil
Cyathula
Curcuminoid
Capsaicin
Chuchuhuasi
Curcumen
Cymbopogon Martini
Centella asiatica
Cetylated Fatty Acids
Cissus sicyoides
Chicken
Curcuma
Calanus finmarchicus
Campsiandra angustifolia
Cowslip
Cannabidiol
Chebulinic acid
Carthamus
Copaiba Oil
Currant
Deer Root
Deer Velvet
Drynaria
Devil's Club
Dwarf Nettle
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Dipsacus
Elephant Vine
Egg
Elk antler
Emu Oil
Eicosapentaenoic Acid
Evening Primrose
Ecklonia
Glycine
Glycosaminoglycans
Little ironweed