Evidence supporting the use of: Chondroitin
For the body system: Joints

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Chondroitin is commonly used as a dietary supplement to support joint health, particularly in the context of osteoarthritis. The rationale for its use is based on its role as a major component of cartilage, where it helps retain water and maintain elasticity. Scientific studies have investigated the efficacy of chondroitin, often in combination with glucosamine. Some randomized controlled trials and meta-analyses have reported modest benefits for pain relief and improved joint function, particularly in individuals with mild to moderate osteoarthritis. However, results are inconsistent, with several high-quality studies and systematic reviews (such as those by the Cochrane Collaboration and the American College of Rheumatology) indicating minimal or no clinically significant benefit compared to placebo. The variability in study outcomes may be due to differences in product formulations, study populations, or methodologies. Safety profiles are generally favorable, with few serious adverse effects reported. Overall, while there is a scientific basis for the use of chondroitin in supporting joint health, the strength of evidence is considered weak to moderate, and major rheumatology guidelines often recommend against its routine use due to the limited clinical benefit demonstrated in rigorous trials.

More about chondroitin
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Other ingredients that support Joints

alfalfa
algal oil
amino acids
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beta caryophyllene
black cumin
black currant
sesame
borage oil
boron
Indian frankincense
bovine
bovine gelatin
broccoli
bromelain
burdock
cabbage leaf
calamari oil
cartilage
cat's claw
cherry
Chinese salvia root
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cissus quadrangularis
collagen
turmeric
curcumin
cuspidatum root
devil's claw
dog rose
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
evening primrose oil
fish oil
fish protein
flavonols
flaxseed
gamma linolenic acid (GLA)
gelatin
ginger
glucosamine
gokhru
gooseberry
gotu kola
green lipped mussel
guggul
horsetail
hyaluronic acid
Indian tinospora
knotweed
krill oil
l-proline
mackerel
manganese
marine lipid
methylsulfonylmethane (MSM)
microcrystalline hydroxyapatite concentrate (MCHC)
milk
moringa
mustard seed
n-acetyl-glucosamine
nettle
olive
omega-3 fatty acids
omega-6 fatty acids
phellodendron amurense
phytocannabinoids
pine bark
pineapple
plantain
protein
quercetin
rehmannia glutinosa
rhizome
rose hips
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sardines
scrophularia root
serratiopeptidase
silicon
black ginger
specialized pro-resolving mediators (SPMs)
triphala
vitamin C
vitamin D
seaweed
water
white willow
wild yam
sarsaparilla
red clover
boneset
chickweed
gastrodia
capsicum
clerodendrum indicum
hedychium spicatum
punarnava
commiphora
paederia foetida
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polyphenols
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barrenwort
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camphor oil
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gentiana macrophylla
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herbal blend (proprietary)
algae
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gravel root
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Boswellic Acid
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Bone Protein
Bee products
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bovine cartilage / glycosaminoglycan
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Bee venom
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Comfrey
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Chinese Silkvine
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Elk antler
Emu Oil
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Evening Primrose Oil
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Other body systems supported by chondroitin

Joints
Skeletal System (Bones)
Spinal Disks
Structural System