Evidence supporting the use of: 10-Undecenoic Acid
For the health condition: Jock Itch
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
10-Undecenoic acid (also known as undecylenic acid) is a fatty acid derived from castor oil and is recognized for its antifungal properties. Its use in the treatment of jock itch (tinea cruris), a fungal infection caused by dermatophytes, is supported by scientific evidence. The antifungal activity of undecylenic acid has been demonstrated in vitro against several species of dermatophytes, including Trichophyton and Epidermophyton species, which are common causes of jock itch. The mechanism involves disruption of fungal cell membrane integrity, leading to inhibition of fungal growth.
Undecylenic acid has been an active ingredient in over-the-counter topical antifungal creams and powders for decades. Several clinical studies and authoritative reviews, such as those cited by the US Food and Drug Administration (FDA) and the United States Pharmacopeia, have acknowledged undecylenic acid's efficacy in the topical treatment of superficial fungal infections, including tinea cruris.
While there are fewer large, randomized controlled trials than for some other antifungals (such as azoles or allylamines), the cumulative laboratory and clinical evidence supports its use, particularly for mild to moderate cases. It is generally regarded as safe for topical use, though it may be less effective than prescription antifungals for severe infections. In summary, undecylenic acid’s use for jock itch is scientifically validated, with moderate quality evidence supporting its efficacy.
Other health conditions supported by 10-Undecenoic Acid
Athlete's FootFungal Infections
Jock Itch
Skin (infections)
Thrush
