Evidence supporting the use of: Scabrous Gentian
For the health condition: Jaundice (adults)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Scabrous Gentian (Gentiana scabra) has a long history of use in traditional Chinese medicine (TCM) and other East Asian medicinal systems for the treatment of jaundice and various liver disorders in adults. In the classical TCM materia medica, Scabrous Gentian—often referred to as "Long Dan Cao"—is described as having properties that "clear heat" and "drain dampness" from the liver and gallbladder meridians, which are believed to underlie symptoms such as jaundice. The use of this herb is documented in ancient texts like the "Shennong Bencao Jing" (Divine Farmer’s Materia Medica), and it remains part of several composite formulas (e.g., Long Dan Xie Gan Tang) still used today for liver-related ailments.

Despite its entrenched position in traditional medicine, scientific validation for the use of Scabrous Gentian specifically in jaundice is limited. Some laboratory and animal studies have explored its hepatoprotective, anti-inflammatory, and antioxidant activities, but direct clinical evidence in humans for the treatment of jaundice is lacking. The rating of "2" reflects that while there is a strong traditional basis and some preliminary pharmacological rationale, robust scientific data from clinical trials is largely absent. Therefore, its use for jaundice is primarily justified by tradition rather than by scientific evidence.

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