Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Polygonum species, particularly Polygonum aviculare (common knotgrass) and Polygonum cuspidatum (Japanese knotweed), have a history of use in traditional medicine systems for various ailments, including those affecting the liver and jaundice. In Traditional Chinese Medicine (TCM), species like Polygonum cuspidatum are used to "clear heat" and "remove toxins," and are sometimes indicated for conditions associated with jaundice, such as damp-heat in the liver and gallbladder. Additionally, some ethnobotanical reports from regions in Asia and Eastern Europe mention the use of Polygonum species decoctions or infusions for liver complaints and to improve bile flow, which historically links them to the management of jaundice.

However, the scientific evidence to support the use of unspecified Polygonum species for jaundice is limited. While some studies have identified hepatoprotective effects in animal models for certain Polygonum extracts, these are not directly focused on jaundice in humans. Most clinical evidence is lacking, and there are no well-designed human trials substantiating their efficacy for treating jaundice specifically. The rating of 2 reflects that there is a clear traditional precedent, but little robust scientific validation. Caution should be exercised as efficacy and safety for this indication are not well-established.

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