Evidence supporting the use of: Vitamin E
For the health condition: Itching

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E has been explored as a treatment for itching (pruritus) primarily due to its antioxidant and anti-inflammatory properties, which could theoretically help in conditions where skin irritation and oxidative stress play a role. Some small clinical studies and case reports have examined the topical or oral use of vitamin E for various types of pruritus, including that associated with chronic kidney disease, atopic dermatitis, and liver disorders. For example, a few randomized controlled trials have indicated that oral vitamin E supplementation may reduce itch intensity in patients with uremic pruritus (itching related to kidney failure). Topical vitamin E has also been used in dermatology for its skin-soothing effects, although the evidence is mostly anecdotal or from small, low-quality studies. Despite these findings, the overall scientific support for vitamin E as a treatment for generalized itching remains weak. Most studies are limited by small sample sizes, short durations, and lack of blinding or rigorous controls. Systematic reviews and dermatology guidelines generally do not recommend vitamin E as a first-line therapy for pruritus, as more robust evidence is needed. However, it may be considered as an adjunct in certain cases, particularly where oxidative stress is implicated, and other treatments have failed. In summary, while there is some scientific investigation into the use of vitamin E for itching, the evidence is modest and does not conclusively validate its efficacy for this purpose.

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