Evidence supporting the use of: Vitamin D
For the health condition: Itching

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin D has some scientific evidence supporting its use in the management of itching (pruritus), particularly in cases associated with certain dermatological conditions. Research indicates that vitamin D plays a role in immune modulation and skin barrier function, which are relevant in disorders where pruritus is a key symptom, such as atopic dermatitis and psoriasis. Several small-scale randomized controlled trials and observational studies have shown that vitamin D supplementation or topical analogs (like calcipotriol) can reduce itch severity in these specific patient populations. For instance, topical vitamin D analogs are commonly used in the treatment of psoriasis, where they help modulate skin cell proliferation and inflammation, indirectly reducing itch. Some studies have also noted benefit in patients with chronic kidney disease-associated pruritus who often have low vitamin D levels. However, the evidence is not robust across all causes of itching, and vitamin D is not universally recommended as a first-line therapy for generalized pruritus. Its benefit seems to be limited to particular subgroups where deficiency or specific pathophysiology is involved. Large-scale, high-quality trials are lacking, and the effect size is generally modest. Therefore, while there is a scientific rationale and some supportive data, vitamin D should not be considered a primary treatment for itching outside of these specific contexts. Supplementation is best guided by documented deficiency or underlying disease processes where evidence exists.

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Other health conditions supported by vitamin D

Acne
Allergies (food)
Allergies (respiratory)
Alzheimer's Disease
Amenorrhea
Anemia
Anorexia
Apathy
Arrhythmia
Arteriosclerosis
Arthritis
Asthma
Autism
Autoimmune Disorders
Backache
Birth Defects (prevention)
Body Building
Broken Bones
Calcium Deficiency
Cancer (natural therapy for)
Cancer (prevention)
Cancer Treatment (reducing side effects)
Cardiovascular Disease
Celiac Disease
Chronic Obstructive Pulmonary Disorder
Colds (antiviral)
Colds (general)
Colds (prevention)
Colds (with fever)
Concentration (poor)
Concussions
Confusion
Congestive Heart Failure
Contagious Diseases
Convalescence
Convulsions
Cramps (menstrual)
Cramps and Spasms
Crohn's Disease
Cystic Breast Disease
Cystic Fibrosis
Dandruff
Debility
Dementia
Depression
Dermatitis
Diabetes
Diabetic Retinopathy
Erectile Dysfunction
Estrogen (low)
Fatigue
Fibroids (uterine)
Fibromyalgia Syndrome
Fibrosis
Grave's Disease
Grief and Sadness
Hair (loss or thinning)
Hair Care (general)
Hashimoto's Disease
Headache (cluster)
Heart (weakness)
Hypertension
Hypothyroid
Infection
Infection (bacterial)
Infection (viral)
Infertility
Inflammation
Inflammatory Bowel Disorders
Influenza
Injuries
Irritable Bowel Syndrome
Itching
Knees (weak)
Leaky Gut Syndrome
Leprosy
Lesions
Leukemia
Lou Gehrig's Disease
Lupus
Lymphoma
Melanoma
Memory and Brain Function
Menopause
Menstrual Irregularity
Mental Illness
Metabolic Syndrome
Migraine
Miscarriage (prevention)
Mood Swings
Multiple Sclerosis
Muscle Tone (lack of)
Muscular Dystrophy
Myasthenia Gravis
Nephritis
Nerve Damage
Nervous Exhaustion
Numbness
Nursing
Obsessive Compulsive Disorder
Oral Surgery
Osteoporosis
Pain (general remedies for)
Pancreatitis
Paralysis
Parkinson's Disease
Peripheral Neuropathy
PMS (general)
PMS Type D
PMS Type H
PMS Type P
PMS Type S
Pneumonia
Polyps
Post Partum Depression
Post Partum Weakness
Pregnancy (herbs and supplements for)
Progesterone (low)
Prostatitis
Psoriasis
Rheumatoid Arthritis
Schizophrenia
Sciatica
Seasonal Affective Disorder
Senility
Tuberculosis