Tea tree oil, derived from the leaves of Melaleuca alternifolia, is commonly used topically to alleviate itching (pruritus) due to its well-documented anti-inflammatory and antimicrobial properties. Scientific studies have provided moderate evidence supporting its efficacy in reducing itching associated with various skin conditions, including dermatitis and insect bites.

A randomized controlled trial published in 2012 evaluated the effect of topical tea tree oil in patients with histamine-induced itch and demonstrated a significant reduction in itch intensity compared to placebo. Other studies have shown benefits for localized itching, particularly in the context of minor wounds, acne, and inflammatory skin conditions, largely attributed to terpinen-4-ol, one of tea tree oil’s main active components.

Furthermore, tea tree oil formulations are included in some over-the-counter products marketed for itch relief. However, the quality and size of available clinical trials vary, and some studies are limited by small sample sizes or lack of blinding. It is also important to note that tea tree oil can cause allergic reactions or skin irritation in some individuals, particularly if used undiluted.

In summary, while there is moderate scientific evidence to support the topical use of tea tree oil for itching, more high-quality, large-scale studies are needed to fully establish its efficacy and safety profile.