Centipeda minima is an herb widely used in Traditional Chinese Medicine (TCM) and other traditional systems, particularly in East and Southeast Asia. In TCM, it is known as "E Bu Shi Cao" and is commonly used to treat various skin disorders, including itching (pruritus), eczema, and allergic reactions. The traditional rationale is based on its reputed ability to "dispel wind," "reduce swelling," and "clear heat," categories under which itching conditions often fall in TCM diagnostics. Herbal compendia and pharmacopoeias, such as the Chinese Pharmacopoeia, list Centipeda minima among herbal remedies for skin conditions featuring itching as a primary symptom.

Scientific studies on Centipeda minima are limited. Some in vitro and animal research indicates anti-inflammatory and anti-allergic properties, which could theoretically contribute to its anti-pruritic effects. For example, extracts of Centipeda minima have been shown to inhibit histamine release and reduce inflammatory cytokines in experimental models. However, clinical trials specifically evaluating its efficacy for treating itching in humans are lacking, and no standardized preparations or dosing guidelines exist in modern medicine for this condition. Thus, while there is some pharmacological basis for its traditional use, direct scientific validation in the context of itching remains insufficient.

In summary, the use of Centipeda minima for itching is primarily justified by tradition, with limited supportive evidence from basic pharmacological research, but no robust clinical trials.