Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Quercetin, a flavonoid found in many fruits and vegetables, has been studied for its anti-inflammatory and antioxidant properties, which are thought to potentially benefit individuals with Irritable Bowel Syndrome (IBS). The rationale for its use in IBS is based on its ability to modulate mast cell activity, reduce intestinal inflammation, and stabilize the gut barrier. Several preclinical studies in animal models have demonstrated that quercetin can decrease intestinal permeability and lower pro-inflammatory cytokine levels, which are relevant mechanisms in IBS pathophysiology. Additionally, small pilot studies and in vitro experiments suggest that quercetin may reduce visceral hypersensitivity, a hallmark of IBS, and improve symptoms such as abdominal pain and bloating. However, clinical evidence in humans is limited. Only a few small trials have evaluated quercetin supplementation in IBS patients, often in combination with other bioactive compounds, making it difficult to attribute effects specifically to quercetin. These studies reported modest improvements in symptoms, but the sample sizes were small and methodologies varied. No large-scale, high-quality randomized controlled trials have confirmed its efficacy for IBS. As such, while there is a plausible scientific basis and some preliminary evidence, the overall quality and quantity of clinical data remain low, resulting in a modest evidence rating. More rigorous research is needed before quercetin can be confidently recommended for IBS management.

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