Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Lactobacillus rhamnosus is a probiotic strain that has been studied for its potential benefits in managing symptoms of Irritable Bowel Syndrome (IBS). Scientific interest in L. rhamnosus for IBS is based on its ability to modulate the gut microbiota, enhance intestinal barrier function, and regulate immune responses. Several randomized controlled trials (RCTs) and meta-analyses have evaluated its efficacy, though results are mixed and strain-specific effects are important. For example, L. rhamnosus GG (LGG) is one of the most extensively studied strains.

Some studies have demonstrated that L. rhamnosus supplementation can reduce IBS symptoms such as abdominal pain, bloating, and stool irregularities, particularly in children and, to a lesser extent, adults. The proposed mechanisms include reduction of gut inflammation, inhibition of pathogenic bacteria, and modulation of gut-brain signaling. However, other trials have failed to show significant benefits over placebo, and heterogeneity in study design, duration, and patient populations complicates interpretation.

Systematic reviews and meta-analyses suggest that while probiotics overall may provide modest benefit for IBS symptoms, the evidence for L. rhamnosus specifically is moderate and not uniformly positive. Major gastroenterology guidelines (such as the ACG) state that probiotics, including L. rhamnosus, may be considered as adjunct therapy, but more high-quality, strain-specific research is needed. In summary, L. rhamnosus is supported by scientific investigation, but the strength of evidence for its use in IBS is moderate (3/5).

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