Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Lactiplantibacillus plantarum is a probiotic bacterium that has been investigated for its potential benefits in managing Irritable Bowel Syndrome (IBS). Multiple randomized controlled trials (RCTs) and systematic reviews suggest that L. plantarum may have a modest but meaningful effect on IBS symptoms, particularly in reducing abdominal pain and bloating. The most studied strain, L. plantarum 299v, has shown efficacy in improving overall IBS symptom scores compared to placebo, with some studies reporting improvements in stool consistency and frequency as well.

The proposed mechanisms by which L. plantarum exerts beneficial effects include modulation of gut microbiota, enhancement of intestinal barrier function, and reduction of gut inflammation. It may also influence visceral hypersensitivity, which is a hallmark feature of IBS. Several meta-analyses published in peer-reviewed journals between 2018 and 2023 have concluded that, while not all patients experience significant benefits, the overall evidence supports the use of certain strains of L. plantarum as an adjunctive therapy for IBS, especially in patients with predominant bloating and abdominal pain.

It is important to note that the quality and size of studies vary, and strain-specific effects are evident—meaning not all L. plantarum strains are equally effective. Still, the cumulative scientific evidence supports its use (evidence level 3/5), though it is not a definitive or standalone treatment.

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