Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavonones (a subclass of flavonoids, often found in citrus fruits) have been investigated for their potential benefits in gastrointestinal disorders, including Irritable Bowel Syndrome (IBS). The primary scientific rationale is their anti-inflammatory, antioxidant, and possible antispasmodic effects on the gut. Some clinical studies have evaluated specific citrus flavonones, such as hesperidin and naringenin, for their impact on gastrointestinal motility, visceral sensitivity, and inflammatory pathways implicated in IBS.

For example, a few small-scale clinical trials have assessed the use of plant extracts rich in flavonones (such as Silexan or citrus extracts) in IBS patients, sometimes demonstrating modest improvements in symptoms like abdominal pain and bloating. Animal and cell culture studies further suggest that flavonones can modulate gut motility and inflammation, which are relevant to IBS pathophysiology.

However, the overall quality of evidence is low: studies are typically small, heterogeneous in design, and often use complex mixtures rather than isolated flavonones. Systematic reviews and meta-analyses have not established a strong consensus for their efficacy in IBS, and leading clinical guidelines do not specifically recommend flavonones for IBS management. In summary, while there is a plausible scientific basis and some early clinical evidence, robust, large-scale trials are lacking and the evidence remains preliminary.

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