Evidence supporting the use of: Vitamin B6
For the health condition: Irritability

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine) has some scientific basis for its use in supporting or treating irritability, though the evidence is limited and not robust. Vitamin B6 is involved in neurotransmitter synthesis, including serotonin, dopamine, and gamma-aminobutyric acid (GABA), all of which play roles in mood regulation. Deficiency in vitamin B6 can lead to neurological symptoms such as irritability, confusion, and depression. Some studies, particularly in children, have found that vitamin B6 supplementation can help reduce symptoms of irritability and behavioral problems, especially in the context of specific deficiencies or metabolic disorders (such as pyridoxine-dependent epilepsy). A few small clinical trials have also explored its role in premenstrual syndrome (PMS), where irritability is a common symptom. These studies suggest mild benefit, but results are inconsistent and often confounded by methodological limitations. For the general population, routine supplementation of vitamin B6 for irritability is not widely recommended due to a lack of high-quality evidence. Overall, while there is a plausible biochemical rationale and some clinical observation supporting the use of vitamin B6 in cases of deficiency or specific syndromes, large-scale, high-quality studies confirming its efficacy for treating general irritability are lacking. Therefore, the scientific support is rated as modest (2 out of 5).

More about vitamin B6
More about Irritability

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