Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Tree Peony (Paeonia suffruticosa) has a long history of use in Traditional Chinese Medicine (TCM), where it is known as "Mu Dan Pi." In TCM, Tree Peony root is often included in formulas to "clear heat," "cool the blood," and "dispel stagnation," which may be interpreted as addressing symptoms like irritability, restlessness, and emotional disturbances. The traditional rationale links irritability to imbalances in the liver and heat in the blood, and Mu Dan Pi is thought to restore balance.

Modern scientific validation for the use of Tree Peony in treating or supporting irritability specifically is limited. Some research has investigated its anti-inflammatory, neuroprotective, and anxiolytic properties, but direct studies on irritability as a clinical endpoint are lacking. Most clinical trials and pharmacological studies focus on related symptoms such as mood regulation, anxiety, or nervous system effects. Thus, while Tree Peony may have some relevant biological activities, the use for irritability is primarily grounded in tradition rather than rigorous scientific evidence.

In summary, Tree Peony’s use for irritability is justified by traditional practices, especially within TCM, but scientific validation remains minimal, and the available evidence is indirect. The overall strength of evidence supporting its use for this condition is low (2 out of 5).

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