Synopsis

Source of validity: Scientific
Rating (out of 5): 1

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system and plays a critical role in reducing neuronal excitability throughout the nervous system. The rationale for using GABA supplements to address irritability is based on its ability to promote relaxation and reduce anxiety, which can contribute to a calmer mood. However, the direct scientific evidence supporting the effectiveness of oral GABA supplementation specifically for treating irritability is limited and weak.

Most studies investigating GABA supplementation focus on its potential to reduce stress and anxiety rather than irritability per se. Some small-scale studies suggest that GABA may have calming effects, but the majority of these studies have methodological limitations, including small sample sizes and lack of rigorous controls. Furthermore, there is ongoing debate about whether orally administered GABA can cross the blood-brain barrier in sufficient quantities to exert a significant effect on brain function.

There are no large, well-controlled clinical trials that directly assess the impact of GABA supplementation on irritability in either the general population or specific clinical groups. Thus, while the use of GABA for irritability is scientifically plausible given its role in the brain, the current level of evidence supporting its efficacy is very low. Most recommendations for GABA in this context are based on extrapolation from its general calming effects rather than direct clinical evidence.

More about GABA (gamma aminobutyric acid)
More about Irritability

Other ingredients used for Irritability

Other health conditions supported by GABA (gamma aminobutyric acid)

Products containing GABA (gamma aminobutyric acid)

Nature's Sunshine Gaba Plus