Evidence supporting the use of: Blue Vervain
For the health condition: Irritability
Synopsis
Source of validity: Traditional
Rating (out of 5): 2
Blue Vervain (Verbena hastata) has a long history of use in traditional herbal medicine, particularly within North American and European herbalism, as a remedy for nervous conditions such as irritability, anxiety, and mild insomnia. Folk practitioners historically described Blue Vervain as a "nervine," believed to have a calming effect on the nervous system. Historical texts and herbal compendiums from the 19th and early 20th centuries reference its use for easing emotional distress, mood swings, and agitation, especially when linked to stress or hormonal changes.
However, the scientific evidence supporting these uses is limited. Modern clinical trials evaluating Blue Vervain’s effectiveness for irritability or related mental health symptoms are lacking. Some laboratory studies have investigated related species (like Verbena officinalis) for possible anxiolytic or sedative properties in animal models, but these findings have not been robustly replicated in human research or specifically for Blue Vervain. The rating of 2 reflects that while the tradition is strong and longstanding, there is little to no high-quality modern scientific evidence to directly support its efficacy for irritability.
Overall, Blue Vervain’s reputation as a calming herb for irritability persists mainly due to its historical use and anecdotal reports, rather than scientific validation.
Other ingredients used for Irritability
5-Hydroxytryptophan (5-HTP)ashwagandha
chamomile
Coptis chinensis
GABA (gamma aminobutyric acid)
lavender
maca
omega-3 fatty acids
passionflower
reishi mushroom
relora® (proprietary)
rhodiola
valerian root
vitamin B6
zinc
amber
St. John's Wort
Avens
Albizia
Dragonhead
Sweet Orange alcohol
Other health conditions supported by Blue Vervain
AnxietyAnxiety Disorders
Appetite (deficient)
Backache
Bites and Stings
Bruises (healing)
Colds (general)
Cramps and Spasms
Depression
Digestion (poor)
Edema
Emotional Sensitivity
Fatigue
Fever
Headache (general)
Indigestion
Inflammation
Insomnia
Irritability
Menstrual Irregularity
Muscle Tone (lack of)
Nervous Exhaustion
Nervousness
Pain (general remedies for)
Post Traumatic Stress Disorder
Stress
Worry
Wounds and Sores