Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Atractylone is a sesquiterpene compound found in Atractylodes species, which are widely used in traditional Chinese medicine (TCM). In TCM, Atractylodes rhizomes are often included in herbal formulas aimed at supporting digestive health, strengthening the spleen, and addressing symptoms such as fatigue and insomnia. However, the traditional rationale for using Atractylodes (and by extension, atractylone) to support or treat insomnia is typically based on TCM theory—such as resolving "dampness" or "Qi deficiency"—rather than direct evidence of sedative or sleep-promoting effects. Scientific studies specifically investigating atractylone’s effects on sleep or insomnia are extremely limited. While some animal studies suggest that atractylone may have anti-inflammatory or neuroprotective properties, there is little to no modern clinical or preclinical research demonstrating efficacy for insomnia. Thus, the use of atractylone for insomnia is rooted in traditional practice, not robust scientific validation, and the evidence supporting its use for this specific condition remains weak.

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