Anemarrhena asphodeloides, known as Zhimu in Traditional Chinese Medicine (TCM), has historically been used for a variety of health concerns, including fever, diabetes, and inflammation. In the context of insomnia, its use is primarily based on traditional practices rather than strong scientific evidence. TCM practitioners often prescribe Anemarrhena asphodeloides as part of multi-herb formulas aimed at nourishing yin and clearing heat, which are believed to contribute to restlessness and insomnia according to TCM theory.

There is limited direct scientific research connecting Anemarrhena asphodeloides or its major constituents (such as timosaponins) to sleep modulation or the treatment of insomnia. Most available studies focus on its anti-inflammatory, antipyretic, and neuroprotective properties rather than its effects on sleep. Some animal studies suggest that extracts from this plant can have sedative effects and may modulate neurotransmitter levels, but these findings are preliminary and not sufficient to establish clinical efficacy for insomnia in humans.

In summary, while Anemarrhena asphodeloides is traditionally used in TCM for symptoms associated with insomnia, robust clinical evidence is lacking. Its use for insomnia should be regarded as tradition-based, and more rigorous scientific studies are needed to substantiate its effectiveness for this indication.