Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin A, including its retinyl forms, has some scientific basis for supporting the healing of injuries, particularly in wound healing and tissue repair. Vitamin A plays a key role in cell growth, epithelialization, and immune function—processes that are critical for proper healing. Animal and human studies have shown that vitamin A deficiency impairs wound healing, while supplementation can improve the healing of skin and mucosal injuries, especially in cases of deficiency or in individuals under metabolic stress (such as after burns or surgery). For example, topical and systemic vitamin A has been used to enhance healing in patients with pressure ulcers or after surgery, with some positive results. The vitamin appears to support collagen synthesis, modulate inflammation, and promote the formation of new blood vessels in healing tissue. However, robust clinical trials in healthy, well-nourished individuals are limited, and most benefits are seen in those with underlying deficiency or increased needs. Furthermore, excessive supplementation may be harmful. Therefore, while there is scientific rationale and some clinical evidence, the overall quality of evidence for routine use of vitamin A specifically for injury treatment in the general population remains moderate to low.

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