Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Transforming Growth Factor Beta (TGF-β) is a cytokine with a well-established role in tissue repair and regeneration. Substantial scientific evidence supports its involvement in the healing processes of various tissues, including skin, bone, cartilage, and tendons. TGF-β is naturally released at sites of tissue injury, where it modulates inflammation, stimulates the proliferation and differentiation of fibroblasts, and promotes extracellular matrix production. These actions are critical for wound healing and scar formation.

Preclinical studies have demonstrated that exogenous application of TGF-β can accelerate wound closure and improve the quality of healed tissue in animal models. For example, studies in rats and rabbits have shown enhanced collagen deposition and re-epithelialization with TGF-β treatment. In bone healing, TGF-β stimulates the recruitment and differentiation of osteoblasts and chondrocytes, which are essential for fracture repair. Clinical research is more limited but has indicated potential benefits in specific scenarios, such as chronic ulcers and some orthopedic applications. However, there are also concerns about excessive scarring and fibrosis when TGF-β activity is dysregulated.

Overall, the use of TGF-β for injury support is strongly grounded in biological research, and its therapeutic applications continue to be explored. While more robust clinical trials are needed for widespread clinical adoption, the current body of evidence supports a scientific rationale for its use in promoting tissue repair.

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