Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Transforming growth factor alpha (TGF-α) is a member of the epidermal growth factor (EGF) family and plays an essential role in cell proliferation, differentiation, and tissue repair. There is scientific evidence from preclinical studies demonstrating that TGF-α can stimulate the proliferation of epithelial and other cell types, accelerate wound closure, and enhance tissue regeneration. Animal models show that topical or local administration of TGF-α can improve healing in various types of injuries, including cutaneous wounds and gastrointestinal mucosal damage. These effects are primarily mediated by the activation of the EGF receptor (EGFR), which triggers downstream signaling pathways involved in cell migration and proliferation. However, clinical use of TGF-α for injury treatment in humans is limited. While recombinant EGF (a related molecule) has been tested in clinical trials for wound healing, direct therapeutic use of TGF-α is less common, possibly due to concerns about its potent mitogenic effects and potential to promote tumorigenesis. Thus, while the biological rationale and preclinical evidence are strong, large-scale clinical trials supporting its routine use in humans for injury repair are lacking. Overall, the use of TGF-α for injury support is based on a solid scientific foundation, but further clinical validation is necessary before it can be widely recommended.

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