Proteolytic enzymes (proteases) such as bromelain, trypsin, and chymotrypsin have been used to support recovery from injuries, particularly soft tissue injuries like sprains, strains, and post-surgical swelling. The scientific rationale is that these enzymes may help reduce inflammation, edema, and pain by breaking down fibrin and other protein debris at injury sites, potentially speeding up the healing process.

Clinical evidence is mixed but suggests some benefit. A few small randomized controlled trials and meta-analyses have found that oral proteolytic enzyme supplements can modestly reduce swelling and improve recovery times after sports injuries or surgery compared to placebo. For example, studies with bromelain and combinations like trypsin/chymotrypsin have reported reductions in pain and swelling, and faster return to function. However, methodological flaws, small sample sizes, and inconsistent results limit the strength of these conclusions.

Major medical organizations do not recommend routine use, and the overall quality of evidence is considered low to moderate. While the use of proteolytic enzymes for injuries is grounded in some scientific research, it is not yet strongly validated, and more high-quality, large-scale studies are needed to confirm efficacy and optimal dosing.