Synopsis

Source of validity: Scientific
Rating (out of 5): 3

L-alanyl-L-glutamine is a dipeptide composed of the amino acids alanine and glutamine, and it is commonly used in clinical nutrition, particularly for patients with injuries, trauma, burns, or those undergoing major surgery. Its use is primarily justified by scientific research rather than tradition. Glutamine is considered a conditionally essential amino acid in times of metabolic stress, such as injury or illness, when the body's demands exceed its ability to produce it naturally.

Scientific studies have demonstrated that L-alanyl-L-glutamine supplementation can help maintain gut barrier function, reduce infection rates, and support immune function in critically ill or injured patients. Its dipeptide form offers greater stability in solutions than free glutamine, which is prone to degradation, making it especially useful in parenteral (intravenous) nutrition.

Several randomized controlled trials and meta-analyses suggest that glutamine supplementation (including as L-alanyl-L-glutamine) may reduce complications and promote recovery in trauma and surgical patients, though results are sometimes mixed, and benefits are most pronounced in patients with severe injuries or critical illness. The evidence is not universally strong or consistent, and some guidelines recommend selective rather than routine use. Nevertheless, the use of L-alanyl-L-glutamine for injury support is grounded in modern clinical research and is recognized in hospital and intensive care settings, meriting a moderate evidence rating.

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