Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Insulin-like growth factor (IGF), particularly IGF-1, is a peptide with well-established roles in cell growth, differentiation, and tissue repair. There is scientific evidence supporting the potential of IGF-1 to aid in the recovery and healing of musculoskeletal injuries, particularly in orthopedic and sports medicine research. Preclinical studies in animal models have shown that IGF-1 can enhance the regeneration of muscle, tendon, and cartilage tissue by stimulating protein synthesis and inhibiting apoptosis (cell death). These findings have prompted exploration into IGF-1 as a therapy for injuries such as muscle strains, tendon ruptures, and cartilage damage.

In human studies, results are more mixed and mostly limited to small clinical trials or case reports. Some research suggests that local administration of IGF-1 (e.g., via injection) may accelerate healing in tendon and muscle injuries, but robust, large-scale, controlled clinical trials are lacking. The evidence supporting systemic IGF-1 administration is even weaker due to concerns about side effects and safety (e.g., risk of abnormal cell growth or cancer). Consequently, while the biological rationale for IGF-1 use in injury treatment is strong and supported by animal data, its clinical application remains experimental and not part of standard medical practice. More research is needed to establish optimal dosing, delivery methods, efficacy, and safety in humans.

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