Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Glutamine is an amino acid that plays a significant role in protein synthesis and immune function. Its use in supporting or treating injuries, particularly in the context of trauma, major surgery, burns, or critical illness, is based on the observation that plasma glutamine levels often decrease during severe physical stress. Some clinical studies have investigated glutamine supplementation for its potential to enhance wound healing, reduce infection rates, and support immune function in injured or critically ill patients.

However, the scientific evidence supporting its routine use for injury recovery in otherwise healthy individuals is limited and mixed. Meta-analyses and systematic reviews involving trauma and surgical patients have shown inconsistent benefits, with some finding modest improvements in infection rates or hospital stay, while others report no significant benefit. Most of the positive findings are confined to specific populations, such as burn victims or critically ill patients receiving enteral or parenteral nutrition.

There is insufficient high-quality evidence to support glutamine supplementation for minor injuries, muscle strains, or general wound healing outside of specialized medical settings. Current guidelines do not recommend its routine use for injury recovery in the general population, but it may be considered in certain clinical scenarios under medical supervision.

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