Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Exo-peptidases, a subclass of proteolytic enzymes, have been investigated for their potential role in supporting the healing of injuries, particularly soft tissue injuries such as sprains, strains, and bruises. The scientific rationale stems from their ability to break down peptide bonds at the ends of protein chains, aiding in the degradation of damaged proteins and inflammatory mediators that accumulate at injury sites. This process is theorized to promote the resolution of inflammation and facilitate tissue repair. Several clinical studies, mostly involving proteolytic enzyme mixtures (which may include exo-peptidases alongside endo-peptidases), suggest modest benefits in reducing swelling, pain, and recovery time compared to placebo. For instance, enzyme preparations like bromelain, trypsin, and chymotrypsin have shown some efficacy in randomized controlled trials for reducing edema and improving functional recovery after musculoskeletal injuries. However, it is often unclear whether the exo-peptidase component is solely responsible for these effects, as most studies use blended enzyme supplements. Despite these findings, the overall quality and quantity of evidence remain limited. Meta-analyses indicate that while there may be some positive effects, the magnitude is typically small, and methodological limitations are common. Thus, while there is some scientific basis for using exo-peptidases to support injury recovery, the evidence does not yet robustly support widespread clinical use, and further high-quality trials are needed to clarify their specific role and efficacy.

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