Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Centella triterpenes, extracted from Centella asiatica (commonly known as Gotu Kola), have been studied for their potential role in supporting wound healing and treating injuries. Scientific evidence indicates that these compounds—primarily asiaticoside, madecassoside, asiatic acid, and madecassic acid—may promote wound repair through several mechanisms. Preclinical studies have demonstrated that Centella triterpenes can enhance collagen synthesis, increase tensile strength of newly formed skin, and stimulate angiogenesis (the formation of new blood vessels), all of which are critical for effective wound healing. In vitro studies suggest these compounds modulate the production of growth factors and cytokines involved in the repair process, while animal models have shown improved wound contraction and faster re-epithelialization. Some small clinical trials have reported positive effects of Centella extracts or triterpenes on wound healing in humans, including improved healing of surgical wounds and burns. However, the number and quality of large, well-controlled clinical trials remain limited, and while results are promising, they are not yet definitive. As such, the use of Centella triterpenes for injury support is supported by a moderate level of scientific evidence, particularly from laboratory and animal studies, with emerging but not conclusive clinical support.

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