Ascorbyl palmitate is a fat-soluble derivative of vitamin C (ascorbic acid) and is sometimes used as a dietary supplement or antioxidant in food products. The use of vitamin C to support or treat influenza has a long history, with both popular and scientific interest. However, most research has focused on ascorbic acid (the water-soluble form), not ascorbyl palmitate. Studies on vitamin C and influenza in general have not demonstrated a significant benefit in prevention or treatment. Systematic reviews and meta-analyses (such as those by the Cochrane Collaboration) have found that vitamin C supplementation does not reduce the incidence of influenza in the general population, though it may slightly reduce the duration and severity of colds (not specifically influenza) in some individuals, especially those under physical stress. There is no high-quality clinical evidence specifically supporting ascorbyl palmitate for influenza. Its use for this purpose is likely based on extrapolation from data on ascorbic acid and historical use of vitamin C for viral infections in general, rather than direct evidence. In summary, scientific evidence for ascorbyl palmitate in the treatment or prevention of influenza is minimal to nonexistent, and it is not recommended as a primary or adjunctive therapy for this condition.