Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavanones are a subclass of flavonoids commonly found in citrus fruits, such as hesperidin, naringenin, and eriocitrin. There is some scientific interest in their potential to support the immune system and combat viral infections, including influenza. Preclinical research, particularly in vitro (cell culture) and some animal studies, suggests that flavanones may possess antiviral activity against influenza viruses. These effects are believed to be due to their antioxidant, anti-inflammatory, and immunomodulatory properties, as well as possible direct inhibition of viral replication and interference with viral entry into host cells.

However, clinical evidence in humans is limited. Most available studies focus on the general antiviral or anti-inflammatory effects of flavanones rather than direct treatment of influenza in human populations. Some studies indicate that flavanone-rich extracts can reduce the severity or duration of cold and flu-like symptoms, but these findings are preliminary and not specific to influenza. As such, while there is a plausible scientific basis for flavanones to be considered supportive agents against influenza, the evidence is not strong or conclusive at this time, and their use is not part of standard clinical guidelines for influenza treatment.

In summary, the use of flavanones for influenza is supported by modest scientific evidence from laboratory and animal studies, but robust clinical trials in humans are lacking, justifying a low evidence rating.

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