Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Black seed (Nigella sativa) has a long history of traditional use in various cultures, particularly in Middle Eastern and South Asian medicine, for supporting immune health and addressing symptoms of respiratory infections, including influenza. Traditional practitioners have valued black seed oil for its purported ability to "strengthen the body" and "fight off colds and flu." The main bioactive compound, thymoquinone, is thought to contribute to these effects. However, while there are preclinical studies suggesting anti-inflammatory, immunomodulatory, and some antiviral properties of black seed extracts, direct scientific evidence specifically supporting its use for treating or preventing influenza in humans is limited. Most of the available research is either in vitro (test tube) or in animal models, showing potential inhibitory effects on certain viruses and positive modulation of immune responses. To date, there are no high-quality human clinical trials confirming efficacy against influenza specifically. Therefore, the use of black seed for influenza is primarily justified by tradition, with only modest preclinical scientific support and a lack of rigorous human studies.

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