Evidence supporting the use of: Vitamin D3
For the health condition: Inflammatory Bowel Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin D3 is used to support or treat Inflammatory Bowel Disorders (IBD), such as Crohn’s disease and ulcerative colitis, based on a growing body of scientific evidence. Epidemiological studies have shown that patients with IBD are more likely to have vitamin D deficiency compared to the general population. This deficiency may be due to malabsorption, reduced sunlight exposure, or chronic inflammation. Vitamin D plays an immunomodulatory role, influencing both innate and adaptive immune responses, which are central to the pathogenesis of IBD. Several observational studies suggest that low vitamin D levels are associated with increased disease activity, higher risk of relapse, and poorer quality of life in IBD patients.

Interventional studies, including randomized controlled trials, have evaluated vitamin D supplementation in IBD. Some have reported that supplementation can reduce disease activity scores, lower inflammatory biomarkers (such as C-reactive protein), and decrease the risk of relapse, especially in patients with established deficiency. However, results are mixed, and not all studies show significant clinical improvement. Meta-analyses generally conclude that while vitamin D supplementation is safe and may provide modest benefits, more large-scale, high-quality trials are needed to confirm its efficacy as a primary or adjunctive therapy for IBD. Overall, scientific evidence supports monitoring and correcting vitamin D deficiency in IBD patients, and supplementation is recommended as part of comprehensive disease management.

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Other ingredients used for Inflammatory Bowel Disorders

2'-Fucosyllactose
7,14-Hydroxy-Docosapentaenoic Acid
Acemannan
Akkermansia muciniphila
Algae
algal oil
Aloe vera
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
andrographolide
anthocyanidins
anthocyanins
apigenin
apocynin
arabinoxylan
arctiin
astragalin
avocado
Bacillus
bacillus clausii
Bacillus licheniformis
bacillus subtilis
bacteria
barberry
barley
Basidiomycota
bentonite
beta caryophyllene
Bifidobacteria
Bifidobacterium
Bifidobacterium adolescentis
Bifidobacterium animalis
Bifidobacterium bifidum
Bifidobacterium breve
Bifidobacterium infantis
Bifidobacterium lactis
Bifidobacterium longum
bioflavonoids
Boswellia
Boswellic Acid
Brassica
butternut
butyrate triglyceride
butyric acid
cannabidiol
casticin
cat's claw
celandine
chamomile
chirata
cichoric acid
citrus pectin
Coptis chinensis
cruciferous
curcumin
dandelion
DHA (docosahexaenoic acid)
eicosapentaenoic acid
ellagitannin
Enterococcus
EPA (eicosapentaenoic acid)
fiber
fish oil
flavans
flaxseed
Frangula
fructooligosaccharides (FOS)
fucoidan
galactooligosaccharides
Glucosinolates
Glutathione
Glycomacropeptides
Glycosphingolipids
Glycyrrhetinic acid
Humic acid
inulin
isomalto-oligosaccharide
Kaempferol
L-glutamine
L. lactis
lactiplantibacillus plantarum
Lactobacillus
Lactobacillus brevis
Lactobacillus casei
Lactobacillus crispatus
Lactobacillus delbrueckii
Lactobacillus fermentum
Lactobacillus gasseri
Lactobacillus johnsonii
Lactobacillus kefiranofaciens
Lactobacillus kefiri
Lactobacillus lactis
Lactobacillus paracasei
Lactobacillus pentosus
Lactobacillus plantarum
Lactobacillus reuteri
Lactobacillus rhamnosus
Lactobacillus sakei
Lactobacillus salivarius
Lactococcus casei
Lactococcus lactis
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Legume protein
licorice root
luteolin
Marshmallow
Myrosinase
Myrrh
N-acetyl-cysteine (NAC)
N-acetyl-glucosamine
Neoandrographolides
nicotinamide riboside
Oligosaccharides
omega-3 fatty acids
Palmitoylethanolamide (PEA)
Pediococcus acidilactici
Pediococcus pentosaceus
Peppermint
phlorotannins
Piperine
polysaccharides
polyunsaturated fat
proanthocyanidins
probiotics
procyanidin
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psyllium
punarnava
punicalagins
reishi mushroom
rosmarinic acid
Rubia cordifolia
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shiitake mushroom
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specialized pro-resolving mediators (SPMs)
spirulina
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Sulfated polysaccharide
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Swertia
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Trametes
tributyrin
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turmeric
Urolithin A
vitamin C
vitamin D
vitamin D3
Xylanase
xylooligosaccharides
Zinc