Evidence supporting the use of: SOD (Superoxide Dismutase, antioxidant activity)
For the health condition: Inflammatory Bowel Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Superoxide Dismutase (SOD) is an endogenous antioxidant enzyme that catalyzes the dismutation of superoxide radicals to hydrogen peroxide and oxygen. Oxidative stress is a well-established pathogenic factor in Inflammatory Bowel Disorders (IBD), including Crohn’s disease and ulcerative colitis. Several preclinical studies in animal models of IBD have demonstrated that administration of SOD, or SOD-mimetic compounds, can reduce colonic inflammation, decrease oxidative damage, and improve histological outcomes. For example, SOD supplementation has been shown to decrease markers of oxidative stress and inflammatory cytokines in rodent colitis models (reference). However, human clinical evidence is limited and inconclusive. A few small clinical trials have investigated orally administered SOD or SOD-rich melon extracts in IBD patients, reporting some improvements in oxidative stress markers but inconsistent effects on clinical symptoms and disease activity (reference). The main limitations are poor oral bioavailability of SOD (as it is degraded in the gut), and the lack of large, well-designed randomized controlled trials. Therefore, while there is a scientific rationale and some preclinical evidence, the clinical evidence supporting SOD use in IBD is weak, justifying a moderate-low evidence rating.

More about SOD (Superoxide Dismutase, antioxidant activity)
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Other ingredients used for Inflammatory Bowel Disorders

2'-Fucosyllactose
akkermansia muciniphila
algal oil
aloe vera
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
anthocyanins
bacillus clausii
bacillus subtilis
barberry
barley
beta caryophyllene
bifidobacterium bifidum
bifidobacterium breve
bifidobacterium infantis
bifidobacterium lactis
bifidobacterium longum
butyrate triglyceride
cat's claw
chamomile
citrus pectin
Coptis chinensis
turmeric
curcumin
dandelion
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
fish oil
flaxseed
fructooligosaccharides (FOS)
inulin
isomalto-oligosaccharide
l-glutamine
lactobacillus brevis
lactobacillus casei
lactobacillus crispatus
lactobacillus fermentum
lactobacillus gasseri
lactobacillus lactis
lactobacillus paracasei
lactiplantibacillus plantarum
lactobacillus reuteri
lactobacillus rhamnosus
lactobacillus salivarius
lactococcus lactis
licorice root
luteolin
marshmallow
n-acetyl-glucosamine
n-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
pectin
peppermint oil
butyric acid
psyllium
reishi mushroom
saccharomyces boulardii
shiitake mushroom
slippery elm bark
specialized pro-resolving mediators (SPMs)
spirulina
streptococcus thermophilus
tributyrin
Urolithin A
vitamin C
vitamin D
vitamin D3
xylanase
xylooligosaccharides
zinc
bentonite
punarnava
rubia cordifolia
swertia
myrrh
algae
7,14-Hydroxy-Docosapentaenoic Acid
Apigenin
Andrographolide
Avocado
anthocyanidins
Acemannan
Arabinoxylan
Apocynin
Arctiin
Astragalin
Bifidobacterium
Bifidobacterium adolescentis
Brassica
Boswellic Acid
Butternut
Basidiomycota
Boswellia
Bacillus licheniformis
Bioflavonoids
Bifidobacterium animalis
Bacteria
Bifidobacteria
Bacillus
Cichoric acid
Cruciferous
Casticin
Celandine
Chirata
Cannabidiol
Enterococcus
Eicosapentaenoic Acid
Ellagitannin
Fucoidan
Fiber
Frangula
Flavans
Glycomacropeptides
Glycosphingolipids
Glutathione
Galactooligosaccharides
Glycyrrhetinic Acid
Glucosinolates

Products containing SOD (Superoxide Dismutase, antioxidant activity)

We currently have no products on Caring Sunshine that contain this ingredient.