Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Polysaccharides, particularly those derived from sources like plants (e.g., aloe vera, psyllium, and certain mushrooms), have been investigated for their potential benefits in treating or supporting Inflammatory Bowel Disorders (IBD) such as Crohn’s disease and ulcerative colitis. The interest in polysaccharides stems from their recognized roles as dietary fibers and their immunomodulatory properties. Scientific studies indicate that some polysaccharides can exert anti-inflammatory effects, modulate gut microbiota, enhance mucosal barrier function, and reduce oxidative stress—all factors relevant to IBD pathogenesis and management. For example, beta-glucans from mushrooms and cereal grains, as well as arabinoxylans from wheat, have shown promising results in preclinical (animal and in vitro) models by reducing markers of inflammation and improving colonic histology. Human studies are more limited but suggest that soluble fibers can be beneficial as adjunct therapy, mainly for symptom relief and gut health.

However, the evidence is not yet robust enough for polysaccharides to be considered stand-alone treatments for IBD. Most clinical trials are small, heterogeneous, and sometimes yield inconsistent results. Nevertheless, numerous reviews and meta-analyses support the idea that certain polysaccharides may provide supportive benefits, especially as part of a broader dietary or adjunctive therapeutic strategy. Thus, the use of polysaccharides in IBD is scientifically grounded, but with moderate evidence, and more rigorous clinical trials are needed.

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