Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Neoandrographolide is a diterpenoid compound derived from Andrographis paniculata, a medicinal plant traditionally used in Asian medicine. In the context of Inflammatory Bowel Disorders (IBD), such as Crohn's disease and ulcerative colitis, there is emerging scientific interest in neoandrographolide due to its anti-inflammatory and immunomodulatory properties. Several in vitro and in vivo animal studies have demonstrated that neoandrographolide can inhibit key pro-inflammatory cytokines (such as TNF-α, IL-1β, and IL-6) and modulate the NF-κB signaling pathway, which plays a central role in intestinal inflammation. For instance, preclinical models of colitis in mice have shown that neoandrographolide administration reduced disease severity, lowered inflammatory markers, and improved histological outcomes in the colon.

However, there are currently no robust clinical trials in humans specifically addressing the efficacy or safety of neoandrographolide for IBD. Most available data are either preclinical or extrapolated from studies on the parent plant extract (Andrographis paniculata), which contains multiple active compounds. Although some small clinical studies have evaluated Andrographis extracts in ulcerative colitis with promising results, it is unclear to what extent neoandrographolide contributes to these effects. Thus, while the scientific rationale is supported by preliminary laboratory research, the clinical evidence in humans is limited, and more studies are needed to establish its therapeutic role in IBD.

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