Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus rhamnosus is a probiotic bacterium that has been studied for its potential benefits in managing Inflammatory Bowel Disorders (IBD), particularly ulcerative colitis and Crohn’s disease. The rationale for its use is rooted in the understanding that IBD is associated with dysbiosis, or an imbalance in gut microbiota, which can exacerbate inflammation. Probiotics like L. rhamnosus are thought to help restore microbial balance, strengthen the intestinal barrier, and modulate immune responses.

Scientific evidence supporting the use of L. rhamnosus in IBD is mixed and mostly modest. Some clinical trials, particularly those involving L. rhamnosus GG (a well-studied strain), have demonstrated benefits in maintaining remission in ulcerative colitis and in preventing or treating pouchitis (a complication after surgery for ulcerative colitis). However, evidence for its effectiveness in Crohn's disease is weaker, with most studies showing minimal or no benefit. Meta-analyses and systematic reviews have generally concluded that while L. rhamnosus may be helpful as an adjunct therapy in specific situations (like pouchitis or mild ulcerative colitis), it should not be considered a primary treatment for IBD.

In summary, the use of L. rhamnosus in IBD is supported by some scientific studies, especially for certain subgroups, but the overall quality and consistency of evidence are moderate at best. Further research is needed to define which patients may benefit most and to clarify optimal dosing and duration.

More about lactobacillus rhamnosus
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