Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Lactiplantibacillus plantarum is a probiotic bacterium that has been investigated for its potential benefits in supporting and treating Inflammatory Bowel Disorders (IBD), including Crohn’s disease and ulcerative colitis. The scientific rationale for its use is grounded in its ability to modulate immune responses, enhance intestinal barrier function, and inhibit the growth of pathogenic bacteria. Several in vitro and animal studies have demonstrated that L. plantarum can reduce pro-inflammatory cytokine production and improve mucosal healing. Additionally, a number of small clinical trials and open-label studies in humans have found that supplementation with L. plantarum (often as part of multi-strain probiotic formulations) may help reduce disease activity, improve symptoms, and prolong remission in patients with IBD.

However, the body of evidence remains moderate. While some randomized controlled trials (RCTs) have shown positive effects—such as reduced relapse rates and improved gut health—other studies have reported minimal or no benefit. For example, a 2004 study published in the journal Gut found that L. plantarum 299v could improve symptoms in patients with irritable bowel syndrome, but its effects in IBD specifically are less consistently demonstrated. Systematic reviews note that while L. plantarum is promising, larger and better-designed clinical trials are needed to confirm its efficacy in IBD management. In summary, L. plantarum is supported by scientific evidence for adjunctive use in IBD, but the strength of evidence is moderate rather than conclusive.

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