Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ellagitannins are polyphenolic compounds found in various fruits and nuts, such as pomegranates, strawberries, and walnuts. Their use in supporting or treating Inflammatory Bowel Disorders (IBD), including Crohn’s disease and ulcerative colitis, is supported by a modest but growing body of scientific research, primarily from preclinical studies. Ellagitannins and their metabolites, such as urolithins, have demonstrated anti-inflammatory and antioxidant properties in laboratory and animal models. Studies have shown that ellagitannins can modulate inflammatory pathways, reduce oxidative stress, and help maintain the integrity of the intestinal barrier. For example, animal models of colitis have shown decreased severity of inflammation and tissue damage when treated with ellagitannin-rich extracts. Limited human studies exist, but emerging clinical data suggest that ellagitannins may positively influence gut microbiota composition and reduce inflammatory markers. However, robust clinical trials in humans with IBD are lacking, and the evidence remains preliminary. Therefore, while the mechanistic rationale and preclinical data are promising, ellagitannin’s use for IBD cannot yet be considered firmly evidence-based or recommended as a primary therapy. More large-scale, controlled human studies are needed to confirm efficacy and safety in this context.

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