Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Celandine (Chelidonium majus) has a long history of use in traditional European herbal medicine, primarily for liver and digestive disorders. Its use in supporting or treating Inflammatory Bowel Disorders (IBD), such as Crohn’s disease or ulcerative colitis, is mainly based on its historical application for general gastrointestinal complaints, including indigestion, biliary disorders, and cramps. There is limited direct evidence from scientific studies specifically evaluating celandine for IBD. Some laboratory and animal studies have shown that celandine extracts possess anti-inflammatory and antispasmodic properties, which may theoretically offer some benefit in inflammatory gut conditions. However, robust clinical trials in humans with IBD are lacking.

Traditionally, celandine was used in various forms (e.g., infusions, tinctures) for its purported ability to relieve gastrointestinal discomfort. Its alkaloid content, including chelidonine, is thought to be responsible for these effects. Despite these traditional claims, modern scientific validation for its efficacy and safety in IBD remains insufficient. Moreover, celandine has been associated with potential hepatotoxicity, raising concerns about its use, especially for prolonged periods or in patients with pre-existing liver conditions. In summary, celandine’s use for IBD is primarily justified by traditional use, with only weak supporting evidence from preclinical studies and no solid clinical validation.

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