Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Bifidobacterium longum is a probiotic bacterium that has been the subject of numerous studies investigating its role in the management of Inflammatory Bowel Disorders (IBD), such as Crohn’s disease and ulcerative colitis. The rationale for its use is primarily scientific, supported by both preclinical and human studies, though the overall quality and consistency of evidence is moderate, hence a rating of 3 out of 5.

Mechanistically, B. longum has been shown to modulate the gut microbiota, enhance the intestinal barrier function, and exert anti-inflammatory effects by downregulating pro-inflammatory cytokines and upregulating anti-inflammatory mediators. Several clinical trials have evaluated the efficacy of B. longum—alone or in combination with other probiotics (such as in the VSL#3 formulation)—in patients with IBD. Some studies demonstrate that supplementation can reduce disease activity, improve clinical symptoms, and help maintain remission, particularly in ulcerative colitis and pouchitis. For example, a randomized controlled trial published in Gut (2004) showed that B. longum with prebiotics improved clinical and histological parameters in ulcerative colitis patients.

However, results are not universally positive, and studies often have limitations in sample size, heterogeneity in probiotic strains, and variations in study design. Systematic reviews and meta-analyses suggest a potential benefit, especially as an adjunct to conventional therapy, but call for more rigorous, large-scale studies. Thus, while scientific evidence exists, it is not yet definitive, and B. longum is generally considered as a supportive rather than primary therapy for IBD.

More about Bifidobacterium longum
More about Inflammatory Bowel Disorders

Other ingredients used for Inflammatory Bowel Disorders

Other health conditions supported by Bifidobacterium longum

Products containing Bifidobacterium longum

Nature's Sunshine Bifidophilus Flora Force
Nature's Sunshine Eleven Elevated (NutriBiome)
Nature's Sunshine Probiotic Eleven
Nature's Sunshine Sunshine Heroes Probiotic Power