Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Barberry (Berberis vulgaris) has a historical use in traditional medicine systems for gastrointestinal complaints, but in recent years, its active constituent, berberine, has attracted scientific interest for its potential therapeutic effects in Inflammatory Bowel Disorders (IBD) such as Crohn’s disease and ulcerative colitis. Several preclinical studies have shown that berberine exhibits anti-inflammatory, antimicrobial, and antioxidant properties, which may help modulate the gut microbiota, reduce mucosal inflammation, and support intestinal barrier function.

Animal models of IBD have demonstrated that barberry extract or isolated berberine can attenuate colonic inflammation, decrease pro-inflammatory cytokines (e.g., TNF-α, IL-6), and ameliorate histological damage. A few small-scale human studies and pilot clinical trials also suggest a potential benefit in reducing disease activity and improving symptoms in patients with ulcerative colitis, though robust, large-scale randomized controlled trials are lacking.

Overall, while the evidence is promising and mechanistically plausible, it is not yet strong enough to recommend barberry as a first-line or standalone therapy for IBD. Its use is supported by both traditional practices and emerging scientific data, but more rigorous human studies are needed to clarify its efficacy and safety profile in this context. As such, barberry may be considered as an adjunctive option, but patients should consult with their healthcare provider before use.

More about barberry
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Other ingredients used for Inflammatory Bowel Disorders

Other health conditions supported by barberry

Products containing barberry

Nature's Sunshine LB Extract
Nature's Sunshine Liquid Cleanse
Nature's Sunshine LIV-J