Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Apigenin is a naturally occurring flavonoid found in various plant foods, including parsley, chamomile, and celery. Its potential use in supporting or treating Inflammatory Bowel Disorders (IBD), such as Crohn's disease and ulcerative colitis, is supported primarily by preclinical scientific evidence. Laboratory and animal studies have demonstrated that apigenin exhibits anti-inflammatory effects, including modulation of cytokine production, inhibition of NF-κB activation, and reduction of oxidative stress—all mechanisms relevant to the pathogenesis of IBD. For example, in rodent models of colitis, apigenin administration has been shown to decrease inflammatory markers, improve histological appearance of the colon, and reduce disease severity.

However, there is a lack of robust clinical data in humans. No high-quality randomized controlled trials have been published demonstrating the therapeutic effects of apigenin in patients with IBD. While the mechanistic and preclinical findings are promising, these results do not always translate into safe and effective therapies for humans. Therefore, while there is a scientific rationale and preliminary evidence for apigenin’s use in IBD, its efficacy and safety remain unproven in clinical settings. The current evidence supporting its use is best described as limited and preclinical, warranting a rating of 2 out of 5.

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