Evidence supporting the use of: Ancylostoma brasiliense
For the health condition: Inflammatory Bowel Disorders
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Ancylostoma brasiliense, a species of hookworm, has been investigated as a potential therapy for inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis. This interest stems from the "hygiene hypothesis," which suggests that a lack of exposure to certain parasites may contribute to the rise in autoimmune and inflammatory diseases in industrialized countries. Experimental studies and limited early-phase clinical trials have explored the deliberate infection of humans with related hookworm species (most notably Necator americanus, but also Ancylostoma duodenale and A. brasiliense) as a means to modulate immune responses and reduce inflammation associated with IBD.
Evidence supporting the use of Ancylostoma brasiliense is mainly preclinical and comes from animal studies, with some small human trials using closely related species. These studies suggest that helminth infection can induce regulatory immune responses, increase anti-inflammatory cytokines like IL-10, and reduce disease severity in experimental models of colitis. However, clinical studies in humans are limited, often underpowered, and sometimes use different hookworm species. There is no large-scale, definitive clinical trial demonstrating clear benefit, and safety concerns remain regarding intentional helminth infection. Thus, while there is a scientific rationale and preliminary data, the overall quality and quantity of evidence is moderate at best, warranting a rating of 3 on the evidence scale.
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alpha-linolenic acid (ALA)
anthocyanins
bacillus clausii
bacillus subtilis
barberry
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beta caryophyllene
bifidobacterium bifidum
bifidobacterium breve
bifidobacterium infantis
bifidobacterium lactis
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citrus pectin
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DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
fish oil
flaxseed
fructooligosaccharides (FOS)
inulin
isomalto-oligosaccharide
l-glutamine
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lactobacillus reuteri
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licorice root
luteolin
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n-acetyl-glucosamine
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nicotinamide riboside
omega-3 fatty acids
pectin
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butyric acid
psyllium
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saccharomyces boulardii
shiitake mushroom
slippery elm bark
specialized pro-resolving mediators (SPMs)
spirulina
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tributyrin
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vitamin C
vitamin D
vitamin D3
xylanase
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zinc
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Other health conditions supported by Ancylostoma brasiliense
Allergies (food)Allergies (respiratory)
Autoimmune Disorders
Colitis
Crohn's Disease
Inflammation
Inflammatory Bowel Disorders
