Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Aloe vera has been traditionally used for a variety of gastrointestinal ailments, and in recent decades, its potential benefits for Inflammatory Bowel Disorders (IBD), such as ulcerative colitis and Crohn’s disease, have attracted scientific interest. The justification for its use in IBD is partially supported by preliminary scientific research, though the overall quality and quantity of evidence are limited, resulting in a modest evidence rating of 2 out of 5.

Several small clinical studies and animal models suggest aloe vera gel, primarily due to its anti-inflammatory and immunomodulatory compounds (such as acemannan and various polysaccharides), may help reduce inflammation and promote mucosal healing in the intestines. The most notable study is a double-blind, randomized, placebo-controlled trial published in 2004 in Alimentary Pharmacology & Therapeutics, in which 44 patients with mild-to-moderate ulcerative colitis received oral aloe vera gel or placebo for four weeks. The aloe vera group showed a higher rate of clinical remission (30% vs. 7%) and improvement (47% vs. 14%) compared to placebo, though the sample size was small and more research is needed.

Despite these promising findings, evidence remains insufficient for routine clinical recommendation. Limitations include small sample sizes, short study durations, and inconsistent results across trials. Most major gastroenterology guidelines do not currently endorse aloe vera for IBD management. Nonetheless, aloe vera continues to be explored as a complementary therapy for its anti-inflammatory properties, but patients should consult healthcare providers before use due to potential side effects and interactions.

More about aloe vera
More about Inflammatory Bowel Disorders

Other ingredients used for Inflammatory Bowel Disorders

Other health conditions supported by aloe vera

Products containing aloe vera

Nature's Sunshine CleanStart Mild
Nature's Sunshine Aloe Vera (Freeze Dried)
Nature's Sunshine Aloe Vera Gel
Nature's Sunshine Aloe Vera Juice
Nature's Sunshine Aloe Vera Juice (Whole Leaf)
Nature's Sunshine Liquid Cleanse