Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Aloe polysaccharides, particularly acemannan and other bioactive sugar molecules found in Aloe vera gel, have been investigated for their potential benefits in inflammatory bowel disorders (IBD) such as ulcerative colitis and Crohn’s disease. Some preclinical studies and a limited number of small human trials suggest potential anti-inflammatory and immunomodulatory effects relevant to IBD. These effects are thought to result from the inhibition of pro-inflammatory cytokines (such as TNF-α, IL-1β, IL-6) and the enhancement of mucosal healing. For example, a randomized, double-blind, placebo-controlled trial (Langmead et al., 2004, Alimentary Pharmacology & Therapeutics) reported modest improvement in symptoms of mild-to-moderate ulcerative colitis with oral Aloe vera gel compared to placebo. Animal studies also support a reduction in colonic inflammation and improved histological outcomes.

However, the clinical evidence remains limited by small sample sizes, short durations, and methodological weaknesses. Major scientific reviews and guidelines do not currently endorse Aloe polysaccharides as standard therapy for IBD. Most evidence comes from in vitro or animal models, with insufficient large-scale human trials to confirm efficacy or safety in this setting. Therefore, while there is a plausible scientific rationale and some preliminary data, the overall evidence supporting Aloe polysaccharides for IBD is weak (rated 2/5) and further research is warranted.

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