Evidence supporting the use of: Vitamin B6
For the health condition: Infertility

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine) has been investigated for its potential role in supporting fertility, particularly in women experiencing luteal phase defects (a condition where the latter part of the menstrual cycle is too short to support pregnancy). Some small clinical studies from the 1970s and 1980s suggested that vitamin B6 supplementation might help lengthen the luteal phase and improve progesterone production, potentially enhancing fertility in women with this specific issue. The mechanism proposed is that vitamin B6 is involved in the synthesis of neurotransmitters and hormones, including those regulating the menstrual cycle, such as prolactin (elevated prolactin can lead to infertility). A few early trials showed that B6 supplementation could lower elevated prolactin levels and help restore normal menstrual cycles. However, the overall scientific evidence is limited and not robust. Most studies are small, dated, and not of high methodological quality. There have not been large, well-designed randomized controlled trials confirming vitamin B6's effectiveness for treating infertility in the general population. Systematic reviews and fertility guidelines typically do not recommend vitamin B6 as a primary treatment for infertility, except in cases of documented deficiency or specific luteal phase issues. Thus, while there is a plausible scientific rationale and limited preliminary evidence, the support for vitamin B6 supplementation in infertility is weak and not conclusive.

More about vitamin B6
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